Can You Really Turn Genes On & Off? The Science Says Yes

By Align/WELL

March 20, 2025

longevity

HIGHLIGHTS:

  • You can influence how your genes behave—without changing your DNA. 
  • Key lifestyle factors like diet, exercise, and stress have a powerful effect on gene expression.
  • Nutrients like folate, polyphenols, and omega-3s help “turn on” genes that support longevity and reduce inflammation.
  • Daily movement activates genes linked to brain health, metabolism, and aging.
  • Mindfulness, good sleep, and low toxin exposure also support healthy gene regulation.
  • Your genes aren’t your destiny—they’re your starting point. Smart choices can shift your biological age.

Your Genes Are Not Your Destiny

Your genes aren't your destiny. Here's how lifestyle habits can help you live longer, feel better, and stay sharp.

Think your DNA controls everything about your health and aging? Not quite.

Groundbreaking research in epigenetics shows that your daily choices—what you eat, how you move, how you manage stress—can flip your genes on or off. That means you have more control over your long-term wellbeing than ever before.

Let’s break it down.

🔑 Quick Wins: How To Influence Your Genes Today  

  • Load up on leafy greens, berries, and omega-3-rich foods
  • Move your body every day—even 30 minutes helps
  • Prioritize sleep and practice mindfulness
  • Swap plastics for glass to reduce toxins

What Is Epigenetics, Really?

Epigenetics is the study of how behaviors and environment can cause changes that affect the way your genes work. These changes don’t alter your DNA, but they do influence how your body reads and acts on that DNA.

Think of your genetic code as the script of a play. Epigenetics is the director, deciding which lines get delivered, which scenes get cut, and how the whole story plays out.

And the best part? You get to help direct the show.

How Lifestyle Influences Gene Expression

🌿 Eat To Turn On Longevity Genes

Your food choices directly impact gene expression through processes like DNA methylation. Some nutrients act like highlighters for your healthiest genes:

  • Folate & B Vitamins (leafy greens, beans, fortified grains): support healthy gene regulation.
  • Polyphenols (berries, tea, red wine, dark chocolate): reduce inflammation and protect DNA.
  • Omega-3s (salmon, flaxseeds, walnuts): support heart health and tame inflammation.

Pro Tip: Add spinach to your morning eggs or toss a handful of walnuts into a smoothie.

🏋️ Exercise: Your Genetic Reset Button

Physical activity activates genes that slow aging, sharpen your brain, and improve metabolism. Just 30 minutes of movement can:

  • Boost brain-derived neurotrophic factor (BDNF), improving cognition
  • Support telomere health, linked to longevity
  • Enhance insulin sensitivity and fat metabolism

No need for marathons—brisk walks, yoga, and strength training all work.

䷉ Stress Is a Gene Disruptor (But You Can Flip the Script)

Chronic stress can mess with gene expression, triggering inflammation and mental health challenges. But you can reverse that pattern:

  • Mindfulness & Breathwork lower stress hormones
  • Sleep allows for gene repair and cellular restoration

Try This: Take 5 deep breaths before meals or set a phone reminder for a daily pause.

🌍 Reduce Toxins, Support Your Epigenome

Your environment influences your genes, too. From plastics to pesticides, everyday toxins can disrupt gene signaling.

Small swaps can make a big difference:

  • Choose glass or stainless steel containers
  • Go organic when possible
  • Use natural cleaning and beauty products

Action Step: Start with just one switch—like trading plastic water bottles for a reusable glass one.

🤓 Real Talk: Epigenetics in Everyday Life

  • Heart Disease in the Family? A diet rich in omega-3s, regular workouts, and stress management can turn down the volume on risky genes.
  • Worried About Brain Health? Healthy habits can boost protective gene expression, even if dementia runs in the family.
  • Poor Vision Genetics? Vitamin A-rich foods like carrots and sweet potatoes can support gene expression tied to eye health.

Your Genes Aren’t Your Fate—They're Just Your Foundation

You were born with a genetic blueprint, but you hold the pen now. Lifestyle changes don’t just make you feel better—they actually help your body express health at the cellular level.

So the next time you choose veggies over processed snacks, lace up your sneakers, or take a deep breath instead of stressing out—know that your genes are listening.

Small habits. Big shifts. That’s the power of epigenetics.


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